C18 LPA

C₂₁H₄₈NO₆P

441.58

NA.25

Lysophosphatidic acid (LPA) is a class of phospholipids, which is water-soluble. It has a glycerol backbone attached via a phosphate group, an aliphatic chain and a hydroxyl group. The aliphatic chain is linked to either sn-1 or sn-2 position and the phosphate group is connected to the sn-3 position. The hydroxyl group is linked to the remaining sn-1 or sn-2 position.

C18 LPA or 1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate may be used:

• to study its effects on Yes-associated protein (YAP) phosphorylation
• as a standard for the quantification of lysophosphatidic acid (LPA) compounds in proton samples using reversed-phase ultra-performance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS)
• as a substrate to investigate the phosphatase activity of soluble epoxide hydrolase (sEH) towards LPA compounds

Lysophosphatidic acid (LPA) is a signaling molecule and alters various cellular responses through G protein-coupled receptors (GPCRs). It stimulates smooth muscle contraction, cytoskeleton rearrangement and chemotaxis. LPA is also involved in inducing neurotransmitter release, cell proliferation, platelet aggregation and Ca²⁺ mobilization. Increased levels of LPA in human plasma leads to ovarian cancer and atherosclerosis. LPA acts as a potential biomarker for ovarian cancer.

>99% (LPA; may contain up to 10% of the 2-LPA isomer)

powder

Avanti Polar Lipids 857228P

dry ice

−20℃

O[C@](COP([O-])(O)=O)([H])COCCCCCCCCCCCCCCCCCC.[NH4+]

5 mL Amber Glass Screw Cap Vial (857228P-1mg)

13 - Non Combustible Solids

WGK 3