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cholestenoic acid-d5
| 产品编号： | 4071044 |
| 规格： | 3β-hydroxy-5-cholestenoic acid-d5, powder |
| CAS NO： | 1620239-03-3 |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Avanti |
| 优惠价： | 立即咨询 |
产品别名
1620239-03-3
cholestenoic acid-d5
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H39 D5O3 |
| Molecular weight | 421.67 |
| NACRES | NA.25 |
| General description【一般描述】 | Cholestenoic acid-d5 is an endogenous cholesterol metabolite. It is produced in extrahepatic organs. Cholestenoic acid levels in plasma ranges between 100-300 nM and is synthesized in brain. Cholestenoic acid is generated by the side chain oxidation of 27-hydroxy-cholesterol and is an intermediate in the bile synthesis pathway. |
| Biochem/physiol Actions【生化/生理作用】 | Cholestenoic acid-d5 functions as a potent steroid γ-secretase modulator (GSM). Cholestenoic acid is a carboxylic acid γ-secretase modulator. Cholestenoic acid also serves as a ligand for liver X receptor. Cholestenoic acid -d5 regulates amyloid β peptides (Aβ) levels. It reduces Aβ42 levels and enhances Aβ38 levels. In retina, it is the major byproduct of cholesterol elimination. 27-hydroxycholesterol and cholestenoic acid are part of reverse cholesterol transport in macrophages and their transport impairment is implicated in premature atherosclerosis. |
产品性质
| Assay【测定】 | >99% (TLC) |
| form【形式】 | powder |
| manufacturer/tradename | Avanti Polar Lipids 700151P |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mL Amber Glass Screw Cap Vial (700151P-1mg) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
