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Cyclotraxin-B trifluoroacetate salt
产品别名
1203586-72-4
Cyclotraxin-B trifluoroacetate salt
L-Cysteinyl-L-asparaginyl-L-prolyl-L-methionylglycyl-L-tyrosyl-L-threonyl-L-lysyl-L-a-glutamylglycyl-L-cysteine, cyclic (1>11)-disulfide
CNPMGYTKEGC (Modifications: Disulfide bridge between 1-11)
基本信息
| Empirical Formula【经验(实验)分子式】 | C48H73N13O17S3 · xC2HF3O2 |
| Molecular weight | 1200.37 (free base basis) |
| Biochem/physiol Actions【生化/生理作用】 | Cyclotraxin-B is a potent and selective Trk B (BDNF/NT-3) receptor inhibitor. Cyclotraxin-B prevents receptor activation by BDNF without interfering with BDNF binding. Cyclotraxin-B has an IC50 value < 1 nM. In rodent studies Cyclotraxin-B, sometimes fused with tat-protein for increased brain permeability, has been shown to have anxiolytic properties, prevent cold hypersensitivity induced by BDNF, and to reduce cocaine self-administration. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | film |
| color【颜色】 | colorless |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
