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MRP3 Knockout HepaRGTM Cells

产品编号:4072572
规格:1 vial
包装规格:1 VIAL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40725721 VIAL12670
基本信息
NACRES
NA.81
General description【一般描述】
HepaRG is a human hepatoma cell line. The cells possess a pseudodiploid karyotype and have been characterized as an oval ductular bipotent hepatic cell line as they have the ability to differentiate into both biliary and hepatocyte lineages in the presence of DMSO. HepaRG MRP3 knockout cells express the major xenobiotic sensors (PXR, CAR and AhR), drug transporters, phase I and II drug metabolizing enzymes as well as key hepatic transcription factors involved in stress response pathways.
Application【应用】
See technical bulletin for detailed protocols
Features and Benefits【特点和优势】
Zinc finger nucleases (ZFN) mediated Knock-out of ABCC3 (MRP3) gene.

  • The frame-shift mutation of ABCC3 gene was confirmed by fragment length analysis and DNA sequencing.
  • Loss of functionality was confirmed by loss of transport of selective substrates in sandwich culture assay.

HepaRG cells are the most metabolically active human hepatocyte cell line developed to date. These the cells are suitable for a wide variety of studies for drug metabolism, CYP induction, metabolism-mediated toxicity, transporter, and hepatotoxicity.

  • Sigma′s HepaRG MRP3 Knockout (KO) allows investigations of drug-transporter interactions involving MRP3 in the liver.
Quality【质量】
Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification, cytochrome oxidase I (COI) analysis for cell line species confirmation.
Legal Information【法律信息】
These products are covered by the License Agreement as described in Exhibit 1 and 2, in the technical bulletin.
HepaRG is a trademark of BioPredic International company
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
human female liver (hepatocarcinoma and hepatitis C)
OMIM accession no.【OMIM登记号】
604323
storage temp.【储存温度】
−196℃
Gene Information
human ... MRP3(8714)
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