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磷酸化EGFR(pSer 1070)ELISA试剂盒
Phospho-EGFR (pSer1070) ELISA Kit
| 产品编号： | 4072859 |
| 规格： | for detection of human, mouse or rat phospho-egfr (pSer1070) in cell and tissue lysates |
| 包装规格： | 1 KIT |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
磷酸化EGFR(pSer 1070)ELISA试剂盒
Phospho-EGFR (pSer1070) ELISA Kit
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | The Human BLC ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BLC in serum, plasma, cell culture supernatants and urine. The EGFR (epidermal growth factor receptor) family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4. EGF R is present on many cell types of epithelial and mesenchymal lineages. The gene EGFR is mapped to human chromosome 7p11.2. |
| Immunogen【免疫原】 | EGFR (pTyr1070) synthetic phosphopeptide |
| Application【应用】 | 请参考Protocol了解详情。 |
| Biochem/physiol Actions【生化/生理作用】 | The members of epidermal growth factor receptor (EGF R) or the ErbB receptor family have been identified as useful biomarkers and targets for cancer therapy. EGF R binds EGF and induces tyrosine phosphorylation leading to proliferation of cells. EGF R is capable of binding transforming growth factor-α and heparin-binding EGF in addition to EGF. There are numerous effector molecules activated by EGF R that result in a variety of biological processes such as morphogenesis, cell motility, apoptosis, differentiation and organ repair and maintenance. Deregulation of EGF R signaling is implicated in progression of a wide variety of tumors, invasion and metastasis. Phosphorylation of Tyr1068 occurs by autophosphorylation of EGF R and is required for the binding of Grb2 (Growth factor receptor-bound protein 2) and activation of ERK1/2 (extracellular signal-regulated kinases) pathway. |
产品性质
| species reactivity | rat, human, mouse |
| technique(s) | ELISA: suitable capture ELISA: suitable |
| input | sample type cell lysate sample type tissue lysate |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... EGFR(1965) |
安全信息
| Pictograms【象形图】 | GHS05,GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H290 - H335 |
| Hazard Classifications【危险分类】 | Met. Corr. 1 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 8B - Non-combustible, corrosive hazardous materials |
