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RituBridge ELISA Kit
基本信息
NACRES | NA.32 |
General description【一般描述】 | A Protein Conformational Array (PCA) in a sandwich ELISA format where the plate is coated with a panel of antibodies raised against peptides derived from the full length protein sequence of Rituximab. Taken individually, each of these antibodies is strongly antigenic to the peptide sequence that was used in its production. However, when these peptides are incorporated into a full length correctly folded protein, the antigenicity of many of them is masked by the three dimensional structure of the protein and only a limited number of the antibodies respond. The result is a histogram which can be likened to a ‘fingerprint′ for correctly folded Rituximab. For a Rituxan Biosimilar, if the protein is correctly folded and glycosylated, the ‘fingerprint′ will match that of Rituximab. If it is not correctly folded, previously masked peptide sequences will be exposed and will be recognized by the antibody made to that exposed sequence. In this way, changes in the ‘fingerprint′ generated by the ELISA will point out differences between the Biosimilar and authentic Rituximab. |
Application【应用】 | For research use only. Not for use in diagnostic procedures. |
产品性质
antibody form【抗体形式】 | IgG fraction of antiserum |
species reactivity | human (Human IgG) |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | 2-8℃ |
安全信息
Pictograms【象形图】 | GHS05 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H290 - H315 - H319 |
Precautionary Statements | P234 - P264 - P280 - P332 + P313 - P337 + P313 - P390 |
Hazard Classifications【危险分类】 | Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 |
Storage Class Code【储存分类代码】 | 8B - Non-combustible, corrosive hazardous materials |