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Trimethoprim Ready Made Solution
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H18N4O3 |
| Molecular weight | 290.32 |
| Application【应用】 | Trimethoprim is used at a final concentration of ~4μg/mL for antibacterial activty. |
| Biochem/physiol Actions【生化/生理作用】 | Trimethoprim is a synthetic derivative of pyrimidine with antibacterial and antiprotozoal properties. Trimethoprim is an inhibitor of bacterial dihydrofolate reductase (DHFR), interfering with the conversion of dihydrofolate (DHF) to tetrahydrofolate (THF). THF is an essential precursor in the thymidine synthesis pathway, interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim′s affinity for bacterial DHFR is several thousand times greater than its affinity for human DHFR. Trimethoprim is potentiated by Sulfonamides and the Trimethoprim-sulfamethazole combination is the most used form. |
产品性质
| biological source【生物来源】 | synthetic |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | liquid |
| concentration【浓度】 | 25 mg/mL in DMSO |
| Mode of action【作用机制】 | DNA synthesis | interferes enzyme | inhibits |
| antibiotic activity spectrum【抗生素抗菌谱】 | Gram-negative bacteria Gram-positive bacteria mycobacteria |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
| Flash Point(F)【闪点(F)】 | 188.6 °F |
| Flash Point(C)【闪点(C)】 | 87 ℃ |
