N^ω-羟基-去甲-L-精氨酸，二醋酸盐-CAS 189302-40-7-Calbiochem

C₅H₁₂N₄O₃ · 2C₂H₄O₂

296.28

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Specifically interacts with the manganese-cluster of the enzyme active site. Does not act as a substrate or as an inhibitor of NOS. Hence, it may serve as a useful tool to study the interplays between arginase and NOS.

Primary Target
arginase from rat liver
Secondary Target
mouse macrophages (IC₅₀ = 50 µM)

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (TLC)

solid

2 μM IC₅₀

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

off-white

water: 50 mg/mL

ambient

−20℃

1, 5 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1