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Caspase-8 Inhibitor II-Calbiochem
| 产品编号： | 4073837 |
| 规格： | The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications. |
| 包装规格： | 250 μG，1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Caspase-8 Inhibitor II-Calbiochem
Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
基本信息
| Empirical Formula【经验(实验)分子式】 | C30H43FN4O11 |
| Molecular weight | 654.68 |
| General description【一般描述】 | A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available. A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target caspase-8 Product does not compete with ATP. Cell permeable: yes Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F* |
| Reconstitution【重悬】 | Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C. |
| Analysis Note【分析说明】 | single spot by TLC |
| Other Notes【其他说明】 | Takizawa, T., et al. 1999. Microbiol. Immunol.43, 245. Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345. Sweeney, E.A., et al. 1998. FEBS Lett.425, 61. Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| form【形式】 | powder |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated |
| color【颜色】 | white to yellow |
| solubility【溶解性】 | DMSO: 10 mM |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 250 μg in Glass bottle 1 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
