MMP-9/MMP-13 Inhibitor I-CAS 204140-01-2-Calbiochem

C₂₅H₂₅N₃O₆S

495.55

A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC₅₀ = 900 pM) and MMP-13 (IC₅₀ = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC₅₀ = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC₅₀ = 930 nM).
A cell-permeable and highly, piperazine-based potent inhibitor of MMP-9 (IC₅₀ = 900 pM) and MMP-13 (IC₅₀ = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC₅₀ = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC₅₀ = 930 nM).

Cell permeable: yes
Primary Target
MMP-9
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 900 pM against both MMP-9 and MMP-13

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Cheng, M., et al. 2000. J. Med. Chem.43, 369.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

white

methanol: 1 mg/mL
DMSO: 100 mg/mL

ambient

−20℃

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1