PP1 Analog-CAS 221243-82-9-Calbiochem

C₁₉H₁₉N₅

317.39

A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1.0 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). Also available in InSolution format (Cat. No. 529605).
A potent, reversible, ATP-competitive, cell-permeable and selective inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). Also available in InSolution format (Cat. No. 529605).

Reversible: yes
Cell permeable: yes
Target IC₅₀: 1.5 nM against I338G mutant v-Src; 1.0 µM against wild-type v-Src; 600 nM against wild-type Fyn
Primary Target
I338G mutant v-Src
Product competes with ATP.

Toxicity: Standard Handling (A)

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.

Bishop, A.C., et al. 2000. Nature407, 395.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.

Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

≥99% (HPLC)

100

solid

Calbiochem^®

OK to freeze

off-white

DMSO: 10 mg/mL

ambient

−20℃

1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)

XSHQBIXMLULFEV-UHFFFAOYSA-N

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1