Withaferin A, Withania somnifera-CAS 5119-48-2-Calbiochem

C₂₈H₃₈O₆

470.60

MFCD10687098

A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC₅₀ = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC₅₀ = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.

Cell permeable: yes
Primary Target
A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
Target IC₅₀: 12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation
Product does not compete with ATP.
Reversible: no

Toxicity: Carcinogenic / Teratogenic (D)

Mohan, R., et al. 2004. Angiogenesis7, 115.
Jeyaprakasam, B., et al. 2003. Life Sci.74, 125.
Devi, P.U., et al. 1995. Cancer Lett.95, 189.
Kupchan, S.M., et al. 1969. J. Org. Chem.34, 3858.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥94% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 10 mg/mL
ethanol: 5 mg/mL

ambient

2-8℃

1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1

DBRXOUCRJQVYJQ-CKNDUULBSA-N

1, 5 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3

438.8 °F

226 ℃