您的位置：首页 > 产品中心 > 73043-80-8， 1-Methyl-7-nitroisatoic anhydride
1-Methyl-7-nitroisatoic anhydride
产品别名
73043-80-8
1-Methyl-7-nitroisatoic anhydride
1M7
1-methyl-7-nitro-2H-3,1-Benzoxazine-2,4(1H)-dione
RNA SHAPE probe
Reagent for RNA SHAPE-MaP
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C9H6N2O5 |
| Molecular weight | 222.15 |
| MDL number | MFCD18432729 |
| Application【应用】 | 1-Methyl-7-nitroisatoic anhydride (1M7) is used as an in vivo SHAPE-MaP reagent for live cell RNA structure analysis at single nucleotide resolution. SHAPE -- or selective 2′-hydroxyl acylation analyzed by primer extension -- uses small, electrophilic chemical probes such as 1M7 to react with the 2′-hydroxyl group and provides insight to RNA structure. When combined with mutational profiling (MaP), quantitative nucleotide measurements are possible for entire transciptomes. Together, these methods deepen the understanding of RNA interactions and regions that may be exploited for design of RNA-targeting small-molecule drugs. |
| Other Notes【其他说明】 | Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing SnapShot: RNA Structure Probing Technologies Detection of RNA-Protein Interactions in Living Cells with SHAPE Standardization of RNA Chemical Mapping Experiments In-cell RNA structure probing with SHAPE-MaP A Fast-Acting Reagent for Accurate Analysis of RNA Secondary and Tertiary Structure by SHAPE Chemistry |
产品性质
| form【形式】 | powder |
| mp | 204.5 ℃ |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
