Amino-PEG4-t-butyl ester

C₁₅H₃₁NO₆

321.41

MFCD11041116

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Real-time monitoring of vesicle pH in an endocytic pathway using an EGF-conjugated two-photon probe

Development of Substrate-Selective Probes for Affinity Pulldown of Histone Demethylases

A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

liquid

reagent type: cross-linking reagent

n/D 1.4508

1.04479 g/mL

−20℃

NCCOCCOCCOCCOCCC(OC(C)(C)C)=O
NCCOCCOCCOCCOCCC(OC(C)(C)C)=O

12 - Non Combustible Liquids

WGK 3