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Fmoc-Asp(CSY)-OH
产品别名
2379679-90-8
Fmoc-Asp(CSY)-OH
(S,Z)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-carboxy-1-cyano-1-(dimethylsulfonio)but-1-en-2-olate
Asp with cyanosulfurylide (CSY)-protected carboxylic acid
Fmoc-protected aspartic acid for minimized aspartimide formation
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C23H22N2O5S |
| Molecular weight | 438.50 |
| Application【应用】 | Fmoc-Asp(CSY)-OH is an Fmoc-protected aspartic acid residue developed in the Bode Lab that contains a cyanosulfurylide (CSY) as a carboxylic-acid protecting group that completely suppresses aspartimide formation in peptide synthesis, a long-standing challenge in peptide chemistry that occurs during Fmoc removal or peptide coupling and affects peptide yield and sequences. Amenable to SPPS, deprotection is achieved under aqueous conditions with electrophilic halogenating agents to convert the ylide to the free acid. Furthermore, the hydrophilic nature of the ylide protecting group improves overall peptide efficiency and solubility. |
| Other Notes【其他说明】 | Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% |
| form【形式】 | powder |
| mp | 157-162 ℃ |
| functional group【官能团】 | Fmoc |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
