β-Secretase Inhibitor II-CAS 263563-09-3-Calbiochem

C₂₅H₃₉N₃O₅

461.59

A potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβ_total (IC₅₀ = 700 nM) and Aβ_1-42 (IC₅₀ = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.
A potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβ_total (IC₅₀ = 700 nM) and Aβ_1-42 (IC₅₀ = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.

Target IC₅₀: 700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively
Product does not compete with ATP.
Reversible: yes
Cell permeable: yes
Primary Target
β-secretase

Toxicity: Standard Handling (A)

Z-Val-Leu-Leu-CHO

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 5 mg/mL

ambient

−20℃

1, 5 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1