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InSolution Q-VD-OPh, Non-O-methylated-Calbiochem
| 产品编号： | 4075245 |
| 规格： | InSolution |
| 包装规格： | 1 MG，5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
InSolution Q-VD-OPh, Non-O-methylated-Calbiochem
N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H25F2N3O6 |
| Molecular weight | 513.49 |
| General description【一般描述】 | A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen. |
| Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Primary Target caspase-1 Cell permeable: yes Target IC50: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively Reversible: no |
| Warning【警告】 | Toxicity: Irritant (B) |
| Sequence【序列】 | Q-Val-Asp-CH₂-OPh |
| Physical form【外形】 | Supplied as a 10 mM (1 mg/195 µl) solution in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). |
| Other Notes【其他说明】 | Braun, J.S., et al. 2007. Exp. Neurol.206, 183. Caserta, T.M., et al. 2003. Apoptosis8, 345. Rebbaa, A., et al. 2003. Oncogene22, 2805. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥90% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Glass bottle 1 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |
