您的位置：首页 > 产品中心 > 187389-52-2， Caspase Inhibitor I-CAS 187389-52-2-Calbiochem
Caspase Inhibitor I-CAS 187389-52-2-Calbiochem
| 产品编号： | 4075612 |
| 规格： | Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor. |
| CAS NO： | 187389-52-2 |
| 包装规格： | 1 MG，5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4075612 | 1 MG | 4360 | |||
| 4075612 | 5 MG | 8410 |
产品别名
187389-52-2
Caspase Inhibitor I-CAS 187389-52-2-Calbiochem
Z-VAD (OMe)-FMK
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H30FN3O7 |
| Molecular weight | 467.49 |
| General description【一般描述】 | A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required. A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells. Shown to enhance the freeze-thaw survival of human embryonic stem cells. When using with purified native or recombinant enzyme, pre-treatment with an esterase is required. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Reversible: no Primary Target Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | Z-Val-Ala-Asp(OMe)-CH₂F* |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C. |
| Analysis Note【分析说明】 | Single spot by TLC |
| Other Notes【其他说明】 | Heng, B.C., et al. 2007. Biosci. Rep.27, 257. Martin, U., et al. 2007. Apoptosis12, 525. Misaghi, S., et al. 2004. Chem. Biol.11, 1677. Joo, C., et al. 1999. Ophthalmic Res. 31, 287. McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229. Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312. Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735. An, S. and Know, K.A. 1996. FEBS Lett.386, 115. Cain, K., et al. 1996. Biochem J.314, 27. Mirzoeva, O.K., et al. 1996. FEBS Lett.396, 266. Pronk, G.J., et al. 1996. Science 271, 808. Slee, E.A., et al. 1996. Biochem. J.315, 21. Chow, S.C., et al. 1995. FEBS Lett. 364, 134. Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283. Zhu, H., et al. 1995. FEBS Lett.374, 303. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 50 mM |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1 |
| InChI key | MIFGOLAMNLSLGH-QOKNQOGYSA-N |
| packaging【包装】 | 1, 5 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
