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1-deoxysphinganine
产品编号: | 4075659 |
规格: | 1-deoxysphinganine (m18:0), powder |
CAS NO: | 196497-48-0 |
包装规格: | 1 MG,10 MG |
产品类别: | 进口试剂 |
品牌: | Avanti |
优惠价: | 立即咨询 |
产品别名
196497-48-0
1-deoxysphinganine
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C18H39NO |
Molecular weight | 285.51 |
NACRES | NA.25 |
General description【一般描述】 | 1-deoxysphinganine is synthesized by the condensation of palmitic acid with alanine or glycine in the presence of enzyme serine palmitoyltransferase (SPT). It is metabolized to 1-deoxyceramides. |
Application【应用】 | 1-deoxysphinganine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line. It is also suitable for use as a neurotoxic agent in human CD8+ T cells. |
Biochem/physiol Actions【生化/生理作用】 | 1-deoxysphinganine elicits cytotoxicity towards dorsal root ganglion (DRG) neurons by disrupting the neuronal cytoskeleton formation. High levels of 1-deoxysphinganine in diabetic patients may contribute to the reduction of pancreatic β cell functionality. In hereditary sensory and autonomic neuropathy type I, mutation in the serine palmitoyltransferase gene results in altered substrate specificity, resulting in the accumulation of 1-deoxysphinganine. |
产品性质
form【形式】 | powder |
manufacturer/tradename | Avanti Polar Lipids 860493P |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
SMILES string | C[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC |
packaging【包装】 | 5 mL Amber Glass Screw Cap Vial (860493P-1mg) 5 mL Amber Glass Screw Cap Vial (860493P-10mg) |
安全信息
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |