[1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) ChemBeads

(C₁₇H₁₄P)₂Fe . PdCl₂

Catalyst for C-C and C-N coupling reaction.
Pd(dppf)Cl₂ may be used as an effective palladium catalyst in the following reactions:

• Cross-coupling of sec-alkyl and n-alkyl Grignard reagents with high yield and selectivity.
• Suzuki coupling of aryl boronic esters with [¹¹C]methyl iodide to form functionalized [¹¹C]toluene derivatives.
• Kumada cross-coupling of 1,3,5-tribromobenzene with Grignard reagents to form star-shaped oligothiophenes.

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads

Versatile Methods to Dispense Sub-Milligram Quantities of Solids using Chemical Coated Beads for High-Throughput Experimentation

ChemBead Enabled High-Throughput Cross-Electrophile Coupling Reveals a New Complementary Ligand

~4 wt.% loading of catalyst

100

solid

GHS08

Danger

H350i

P201 - P202 - P280 - P308 + P313 - P405 - P501

Carc. 1B Inhalation

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK 3