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4′-Hydroxy carvedilol
产品别名
142227-49-4
4′-Hydroxy carvedilol
4-(2-(3-(9H-carbazol-4-yloxy)-2-hydroxypropylamino)ethoxy)-3-methoxyphenol
BM 14686
4′-OH carvedilol
4′-Hydroxyphenyl carvedilol
4′OH-CVD
4-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol
Carvedilol metabolite M4
BM 140686
4OHC
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H26N2O5 |
| Molecular weight | 422.47 |
| General description【一般描述】 | Carvedilol is a β- and α1-adrenoreceptor blocker for the treatment of hypertension and congestive heart failure (CHF). The drug is metabolized by CYP2D6 (to 4′-OH and 5′-OH), CYP2C9 (to O-desmethyl), CYP1A2 (to 8-OH). It is also oxidized to 1-OH carvedilol, but the enzyme involved is not yet clear. These metabolites are useful markers for studying and monitoring the activities of cytochrome metabolizing enzymes. M4 metabolite (4′-OH), but not M2 or M5, is most likely to contribute to total β-adrenoceptor blocking activity due to its higher potency. |
| Application【应用】 | Metabolomics |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% |
| form【形式】 | solid |
| color【颜色】 | off-white to white |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
