Histamine, Free Base-CAS 51-45-6-Calbiochem

C₅H₉N₃

111.15

MFCD00005210

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase. Formed by the decarboxylation of L-histidine. Activation of histamine H₁ receptors leads to Ca²⁺ mobilization, whereas histamine H₂ receptor activation stimulates adenylate cyclase activity in neurons. Stimulated time- and concentration-dependent increase in p38 and p42/p44 MAP kinases in DDT(1) MF2 cells.
A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase.
A potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H₁ receptors leads to Ca²⁺ mobilization; whereas, histamine H₂ receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H₂ receptor activation.

Toxicity: Harmful (C)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol.133, 178.
Izumi, H., et al. 1995. Am. J. Obstet. Gynecol.172, 1477.
Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem.269, 9952.
Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (TLC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

white

water: 1 mg/mL

ambient

2-8℃

1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)

NTYJJOPFIAHURM-UHFFFAOYSA-N

1 g in Glass bottle
5 g in Plastic ampoule
Packaged under inert gas

GHS06,GHS08

Danger

H301 - H315 - H317 - H319 - H334 - H335

P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Respiratory system

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3