您的位置：首页 > 产品中心 > 32675-71-1， DNA Methyltransferase Inhibitor-CAS 32675-71-1-Calbiochem
DNA Methyltransferase Inhibitor-CAS 32675-71-1-Calbiochem
| 产品编号： | 4076710 |
| 规格： | The DNA Methyltransferase Inhibitor, also referenced under CAS 32675-71-1, controls the biological activity of DNA Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications. |
| CAS NO： | 32675-71-1 |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
32675-71-1
DNA Methyltransferase Inhibitor-CAS 32675-71-1-Calbiochem
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H14N2O4 |
| Molecular weight | 334.33 |
| General description【一般描述】 | A cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Reversible: no Primary Target CPG methylase M.Sssl |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Brueckner, B., et al. 2005. Cancer Res.65, 6305. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| potency【效能】 | 115 nM IC50 |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 100 mg/mL methanol: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25) |
| InChI key | HPTXLHAHLXOAKV-UHFFFAOYSA-N |
| packaging【包装】 | 10 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
