Gambogic Acid, Garcinia hanburyi-CAS 2752-65-0-Calbiochem

C₃₈H₄₄O₈

628.75

A cell-permeable, anti-microbial xanthone orignally isolated from the gamboge resin of Garcinia hanburyi. Acts as a caspase activator and apoptosis inducer. Shown to inhibit the growth of HeLa and HEL cells (MIC = 12.5 µg/ml). Reported to block telomerase activity in SMMC-7721 cells. Shown to induce tyrosine kinase phosphatase SHP-1 and suppress Stat3 activation.
A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Shown to inhibit the growth of HeLa and HEL cells minimal inhibitory concentrations (MIC = 12.5 µg/ml).

Cell permeable: yes
Primary Target
Caspase activator and an apoptosis inducer
MIC = 12.5 µg/ml in inhibiting the growth of HeLa and HEL cells
Product does not compete with ATP.
Reversible: no

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Prasad, S., et al. 2011. Cancer Prev. Res.4, 1084.
Guo, Q.L., et al. 2004. Acta Pharmacol. Sin.25, 769.
Asano, J., et al. 1996. Phytochemistry41, 815.
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CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (TLC)

amorphous solid

Calbiochem^®

OK to freeze
protect from light

orange

DMSO: 10 mg/mL
ethanol: soluble

ambient

2-8℃

1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23?,27?,36-,37?,38-/m1/s1

GEZHEQNLKAOMCA-PLUQQRNKSA-N

25 mg in Alu drum
Packaged under inert gas

GHS06

Danger

H301 - H315 - H319 - H335

P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Respiratory system

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 1