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U0126-CAS 109511-58-2-Calbiochem
| 产品编号： | 4077743 |
| 规格： | U0126, CAS 109511-58-2, is a potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. |
| CAS NO： | 109511-58-2 |
| 包装规格： | 1 MG，5 MG，10 MG，20 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4077743 | 1 MG | 1390 | |||
| 4077743 | 5 MG | 3940 | |||
| 4077743 | 10 MG | 6120 | |||
| 4077743 | 20 MG | 10050 |
产品别名
109511-58-2
U0126-CAS 109511-58-2-Calbiochem
1,4-Diamino-2,3-dicyano-1,4- bis(2-aminophenylthio)butadiene, MEK Inhibitor VI
1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene, MEK Inhibitor VI
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H16N6S2 · 0.5C2H6O |
| Molecular weight | 403.52 |
| NACRES | NA.77 |
| General description【一般描述】 | A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to MEK substrates, ATP and ERK. Has very little effect on other kinases, such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Shown to block doxazosin-induced osteoblastic differentiation. U0126 also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Noncompetitive with respect to ATP. Also available in InSolution A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Shown to block doxazosin-induced osteoblastic differentiation. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Noncompetitive with respect to ATP. Also available in InSolution |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target MEK1 and MEK2 Product does not compete with ATP. Target IC50: 72 nM, 58 nm, against MEK1, and MEK2, respectively Reversible: no Cell permeable: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Unstable in solution; reconstitute just prior to use. |
| Other Notes【其他说明】 | Choi, Y.J., et al. 2011. Biochem. Biophys. Res. Commun.416, 232. DeSilva, D.R., et al. 1998. J. Immunol. 160, 4175. Duncia, J.V., et al. 1998. Biorg. Med. Chem. Lett.8, 2839. Favata, M.F., et al. 1998. J. Biol. Chem. 273, 18623. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 200 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+ |
| InChI key | DVEXZJFMOKTQEZ-JYFOCSDGSA-N |
| packaging【包装】 | 1, 5 mg in Glass bottle 10, 20 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
