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MT1-MMP, Catalytic Domain, Human, Recombinant, E. coli

产品编号:4077755
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
407775510 μG10260
产品别名

MT1-MMP, Catalytic Domain, Human, Recombinant, E. coli

MMP-14 Catalytic Domain

产品性质
Assay【测定】
≥90% (SDS-PAGE)
Quality Level【质量水平】
100
form【形式】
liquid
Specific Activity
≥140 mU/mg protein
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
avoid repeated freeze/thaw cycles
shipped in【运输】
wet ice
storage temp.【储存温度】
−70℃
packaging【包装】
10 μg in Plastic ampoule
Please refer to vial label for lot-specific concentration.
基本信息
General description【一般描述】
Recombinant, human pro-MT1-MMP expressed in E. coli and activated to yield the active catalytic domain (amino acids 89-265). Degrades fibrillar collagen Types I, II, and III, as well as other extracellular matrix proteins, and activates MMP-2 and MMP-13 resulting in enhanced proteolysis of the matrix for cell migration and proliferation.
Note: 1 mU = 1 milliunit.
Recombinant, human pro-MT1-MMP expressed in E. coli and activated to yield the active catalytic domain (amino acids 89-265). The catalytic domain is comprised of amino acid residues Tyr89 to Gly265 of mature human MT1-MMP. Hydrolyzes fibrillar collagens I, II, and III, as well as other extracellular matrix proteins, and activates MMP-2 and MMP-13, resulting in enhanced proteolysis of the matrix for cell migration and proliferation.
Warning【警告】
Toxicity: Standard Handling (A)
Physical form【外形】
In 150 mM NaCl, 50 mM Tris-HCl, 5 mM CaCl₂, pH 7.5.
Reconstitution【重悬】
Following initial thaw, aliquot and freeze (-70°C).
Other Notes【其他说明】
Amano, T., et al. 2005. Cell Res.15, 150.
Knauper, V., et al. 1996. J. Biol. Chem. 271, 17124.
Pei, D., and Weiss, S.J. 1996. J. Biol. Chem. 271, 9135.
Sato, H., et al. 1994. Nature370, 61.
Knight, C.G., et al. 1992. REBS Lett.296, 263.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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