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AEBSF, Hydrochloride-CAS 30827-99-7-Calbiochem
| 产品编号： | 4077843 |
| 规格： | AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP. |
| CAS NO： | 30827-99-7 |
| 包装规格： | 50 MG，100 MG，500 MG，1 G |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4077843 | 50 MG | 1190 | |||
| 4077843 | 100 MG | 1710 | |||
| 4077843 | 500 MG | 6120 | |||
| 4077843 | 1 G | 10840 |
产品别名
30827-99-7
AEBSF, Hydrochloride-CAS 30827-99-7-Calbiochem
基本信息
| Empirical Formula【经验(实验)分子式】 | C8H10FNO2S · xHCl |
| Molecular weight | 203.23 (free base basis) |
| MDL number | MFCD00132962 |
| General description【一般描述】 | AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP. Specific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K. Specific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications. Also available as a 50 mM solution in H2O (Cat. No. 508436). |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target chymotrypsin Product does not compete with ATP. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9). |
| Other Notes【其他说明】 | Citron, M., et al. 1996. Neuron 17, 171. Ohkubo, I., et al. 1994. J. Biochem. 116, 1182. Mintz, G.R. 1993. BioPharm. 6, 34. Lawson, W.B., et al. 1982. Folia Haematol.109, 52. Markwardt, F., et al. 1974. Biochem. Pharmacol.23, 2247. Markwardt, F., et al. 1973. Thromb. Res.2, 343. Baker, B.R., and Cory, M. 1971. J. Med. Chem.14, 119. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | >97% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | water: 25 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H |
| InChI key | WRDABNWSWOHGMS-UHFFFAOYSA-N |
| packaging【包装】 | 500 mg in Plastic ampoule 1 g in Glass bottle 50, 100 mg in Glass bottle Packaged under inert gas |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 |
| Precautionary Statements | P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
