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5-Aza-2'-Deoxycytidine-CAS 2353-33-5-Calbiochem
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4078481 | 25 MG | 4470 |
产品别名
2353-33-5
5-Aza-2'-Deoxycytidine-CAS 2353-33-5-Calbiochem
5-Aza-CdR, 5-Aza-dC, 2′-Deoxy-5-azacytidine, Decitabine
基本信息
| Empirical Formula【经验(实验)分子式】 | C8H12N4O4 |
| Molecular weight | 228.21 |
| MDL number | MFCD00043011 |
| General description【一般描述】 | A cytosine analog that acts as a DNA methyltransferase inhibitor. Shown to restore mRNA and protein expression of caspase-8 and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) sensitivity of resistant cell lines. Also reported to enhance apoptosis induced by histone deacetylase (HDAC) inhibitors. A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. Also available as a 100 mM solution in DMSO (Cat. No. 189826). |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target DNA methyltransferase inhibitor |
| Warning【警告】 | Toxicity: Harmful & Carcinogenic / Teratogenic (E) |
| Preparation Note【制备说明】 | warming is required to achieve complete solubilization |
| Reconstitution【重悬】 | Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Eggert, A., et al. 2001. Cancer Res.61, 1314. Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921. Zhu, W.G., et al. 2001. Cancer Res.61, 1327. Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315. Haaf, T. 1995. Pharmacol. Ther.65, 19. Jones, P.A., and Taylor, S.M. 1980. Cell20, 85. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | lyophilized |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| solubility【溶解性】 | methanol: 1 mg/mL 50% acetic acid: 25 mg/mL DMSO: 25 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15) |
| InChI key | XAUDJQYHKZQPEU-UHFFFAOYSA-N |
| packaging【包装】 | 25 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H302 - H315 - H319 - H335 - H341 - H360 |
| Precautionary Statements | P201 - P202 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
