Zebularine-CAS 3690-10-6-Calbiochem

C₉H₁₂N₂O₅

228.20

MFCD04973699

A cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
A chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
Cytidine deaminase

Toxicity: Standard Handling (A)

Slight warming may be required to achieve complete solubilization.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.





From Catalog:

Desc. Field- added "cell-permeable"

Cheng, J.C., et al. 2004. Cancer Cell6, 151.
Cheng, J.C., et al. 2003. J. Natl. Cancer Inst.95, 399.
Zhou, L., et al. 2002. J. Mol. Biol.321, 591.
Barchi, J.J., Jr., et al. 1992. J. Org. Chem.57, 536.
Frick, L., et al. 1989. Biochemistry28, 9423.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze

off-white

DMSO: 5 mg/mL
methanol: 5 mg/mL

wet ice

2-8℃

1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2

RPQZTTQVRYEKCR-UHFFFAOYSA-N

10, 25 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3