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JNK 抑制剂 II-CAS 129-56-6-Calbiochem
JNK Inhibitor II-CAS 129-56-6-Calbiochem
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4079320 | 5 MG | 1390 | |||
4079320 | 25 MG | 3940 | |||
4079320 | 50 MG | 6120 |
产品别名
129-56-6
JNK 抑制剂 II-CAS 129-56-6-Calbiochem
JNK Inhibitor II-CAS 129-56-6-Calbiochem
SAPK Inhibitor II, Anthra[1,9- cd]pyrazol-6(2 H)-one, 1,9-pyrazoloanthrone, SP600125
基本信息
Empirical Formula【经验(实验)分子式】 | C14H8N2O |
Molecular weight | 220.23 |
General description【一般描述】 | A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available. |
Biochem/physiol Actions【生化/生理作用】 | Target IC50: 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3 Primary Target JNK 1, JNK 2, JNK 3 Reversible: yes Cell permeable: yes Product competes with ATP. |
Warning【警告】 | Toxicity: Standard Handling (A) |
Preparation Note【制备说明】 | For every 10 µM concentration of JNK Inhibitor II, include 0.1% DMSO in the culture medium. Pre-warming of culture medium and addition of BSA to the medium may enhance its solubility. |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C. |
Other Notes【其他说明】 | Shin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta1589, 311. Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA98, 13681. Han, Z., et al. 2001. J. Clin. Invest.108, 73. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 200 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | yellow-orange |
solubility【溶解性】 | DMSO: 15 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
InChI | 1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) |
InChI key | ACPOUJIDANTYHO-UHFFFAOYSA-N |
packaging【包装】 | 5, 25, 50 mg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |