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Anti-PABPC1/C3 Antibody
| 产品编号： | 4079480 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PABPC1/C3 Antibody
Polyadenylate-binding protein 1, PABP-1, Poly(A)-binding protein 1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Poly(A)-binding proteins, cytoplasmic 1 (PABPC1), and cytoplasmic 3 (PABPC3) are RNA-binding proteins with important roles in post-translational control and metabolism of mRNA. Although both proteins bind to the poly(A) tail of mRNA, PABPC3 binds with a lower affinity than PABPC1. Studies have associated these proteins with tumorigenesis. Decreased expression of PABPC1 in esophageal cancer seems to associate with tumor development and poor prognosis after surgery. PABPC1 can shuttle through the nuclear membrane and is thought to associate with newly synthesized poly(A) transcripts. PABPC1 has also been linked to microRNA mediated silencing when in contact with GW182. PABPC3 is thought to be specific to human testis and controls RNA stability. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human PABPC1/C3. The immunogen sequence used is 100% identical to both PABPC1 and PABPC3. |
| Application【应用】 | Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected PABPC1/C3 in NIH/3T3 and HeLa cells. Use Anti-PABPC1/C3 (Rabbit Polyclonal Antibody) validated in ICC, WB to detect PABPC1/C3 also known as Polyadenylate-binding protein 1, PABP-1. Research Category Epigenetics & Nuclear Function Research Sub Category RNA Metabolism & Binding Proteins |
| Quality【质量】 | Evaluated by Western Blot in HeLa cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected PABPC1/C3 on 10 µg of HeLa cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control HeLa cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse, human |
| species reactivity (predicted by homology) | chicken (based on 100% sequence homology), Xenopus (based on 100% sequence homology), bovine (based on 100% sequence homology), canine (based on 100% sequence homology), rat (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_002559 |
| UniProt accession no.【UniProt登记号】 | P11940 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~71 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
