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Suramin sodium salt
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4079516 | 25 MG | 1150 | |||
4079516 | 100 MG | 1920 |
产品别名
129-46-4
Suramin sodium salt
Suramine sodium salt
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C51H34N6Na6O23S6 |
Molecular weight | 1429.17 |
Beilstein | 3694087 |
EC number【EC 号】 | 204-949-3 |
MDL number | MFCD00210217 |
PubChem Substance ID【PubChem化学物质编号】 | 24277738 |
NACRES | NA.25 |
General description【一般描述】 | Suramin is an antiparasitic drug, which blocks endothelial cell proliferation and increases tyrosine phosphorylation of many signalling proteins. It is associated with urticaria, paresthesias, vomiting and neurologic toxicity. Suramin is used to treat trypanosomiasis and onchocerciasis. It functions as an inhibitor of heparanase and also exhibits anti-AIDS (acquired immunodeficiency syndrome) property. |
Application【应用】 | Suramin sodium salt has been used:
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Biochem/physiol Actions【生化/生理作用】 | Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity. |
产品性质
Quality Level【质量水平】 | 200 |
Assay【测定】 | ≥98% (TLC) |
solubility【溶解性】 | H2O: >10 mg/mL |
SMILES string | [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1ccc(cc1NC(=O)c2cccc(NC(=O)Nc3cccc(c3)C(=O)Nc4cc(ccc4C)C(=O)Nc5ccc(c6cc(cc(c56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c2)C(=O)Nc7ccc(c8cc(cc(c78)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O |
InChI | 1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6 |
InChI key | VAPNKLKDKUDFHK-UHFFFAOYSA-H |
Gene Information | human ... EGF(1950), FGF1(2246), P2RX1(5023), P2RY1(5028), PDGFA(5154), PLD1(5337) |
packaging【包装】 | 100, 500 mg in poly bottle |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |