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Anti-Potassium Channel KCNQ5 Antibody
| 产品编号： | 4079612 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Potassium Channel KCNQ5 Antibody
Potassium voltage-gated channel subfamily KQT member 5, Potassium channel subunit alpha KvLQT5, KQT-like 5, Voltage-gated potassium channel subunit Kv7.5, KCNQ5
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | KCNQ5 is subunit one of a voltage gated potassium channel expressed in the brain and other tissues. KCNQ5 forms the complete channel with KCNQ3. This channel gives rise to the "M" potassium current which is a slowly activating and deactivating current. This current plays a critical role in determining the subthreshold electrical excitability of neurons. KCNQ5 is strongly expressed in the brain but also in skeletal muscle and vascular smooth muscle cells. KCNQ5 activity is also regulated via phosphorylation by PKC and that kinase regulation may be a key to regulating excitability in neurons and muscle cells. |
| Specificity【特异性】 | Western Blotting Analysis was tested on overxpressing transfected cell lysate. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the Human Potassium Channel KCNQ5. |
| Application【应用】 | This Anti-Potassium Channel KCNQ5 Antibody is validated for use in Immunohistochemistry and Western Blotting for the detection of Potassium Channel KCNQ5. Research Category Neuroscience Western Blotting Analysis: A 0.1µg/mL dilution from a representative lot detected Potassium Channel KCNQ5 in 10 µg of transient over-expression of Potassium Channel KCNQ5 in HEK293 cell lysate. |
| Quality【质量】 | Evaluated by Immunohistochemistry in human cerebral cortex tissue. Imunnohistochemistry Analysis: A 1:2,000 dilution of this antibody detected Potassium Channel KCNQ5 in human cerebral cortex tissue. |
| Linkage【联系】 | Replaces: AB5599 |
| Physical form【外形】 | Purified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Antigen Affinity Purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, rat |
| species reactivity (predicted by homology) | canine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), giant panda (based on 100% sequence homology), feline (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_062816 |
| UniProt accession no.【UniProt登记号】 | Q9NR82 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~103 kDa observed. Predicted to cross react to Isoforms 1, 2, and 3. Additional bands are detected in endogenous lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
