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Anti-GluR1 Antibody
| 产品编号： | 4079701 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-GluR1 Antibody
Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Glutamate receptors (GluRs) are a diverse group responsible for mediating most of the excitatory synaptic transmission in the CNS of vertebrates. They can be categorized as ionotropic or metabotropic and subcategorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this position is occupied by a Gln residue. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling. |
| Specificity【特异性】 | This antibody recognizes the extracellular domain of GluR1. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the extracellular domain of rat GluR1. |
| Application【应用】 | Anti-GluR1 Antibody is a highly specific rabbit polyclonal antibody, that targets GluR1 & has been tested in western blotting & IHC (Paraffin). Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected GluR1 in human brain and human cerebellum tissue. |
| Quality【质量】 | Evaluated by Western Blotting in rat brain tissue lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected GluR1 in 10 µg of rat brain tissue lysate. |
| Linkage【联系】 | Replaces: PC246-100UG |
| Other Notes【其他说明】 | Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, mouse, human |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_113796 |
| UniProt accession no.【UniProt登记号】 | P19490 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~110 kDa observed |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
