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Anti-phospho-α-B Crystallin (14-25) (pSer19) antibody produced in rabbit
| 产品编号： | 4079712 |
| 规格： | affinity isolated antibody, lyophilized powder |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD07370435 |
| NACRES | NA.41 |
| Specificity【特异性】 | Does not detect the unphosphorylated protein. |
| Immunogen【免疫原】 | synthetic phosphopeptide surrounding the region of human α-B crystallin that contains serine 19. |
| Application【应用】 | Anti-phospho-α-B Crystallin (14-25) (pSer19) antibody produced in rabbit
|
| Biochem/physiol Actions【生化/生理作用】 | α-Crystallin B chain is a protein encoded by the CRYAB gene in humans. αB-crystallin (ABC) and HSP27 are most abundant in human tissues. It is predominantly expressed in triple-negative breast cancer (TNBC) and leads to aggressive tumor phenotype. αB-crystallin expression is primary found in breast carcinomas and brain metastases. αB-crystallin is overexpressed or silenced in two different TNBC cell lines. It is a novel regulator of brain metastasis in TNBC and acts as a potential biomarker for drug target in aggressive disease. αB-crystallin and VEGF expressions in human conjunctival squamous cell carcinoma (CSCCs) may play an important role in the pathogenesis. Mutation in the gene is responsible for a number of inherited human disorders, which include cardiomyopathy, skeletal muscle myopathy and cataracts. |
| Physical form【外形】 | Lyophilized from phosphate buffered saline, pH 7.4, containing 3% bovine serum albumin and 0.05% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | lyophilized powder |
| species reactivity | mouse, rat, human, bovine |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10 μg/mL indirect immunofluorescence: 5 μg/mL western blot: 0.5 μg/mL using human cell extract |
| UniProt accession no.【UniProt登记号】 | P02511 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CRYAB(1410) mouse ... Cryab(12955) rat ... Cryab(25420) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
