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Anti-VAMP-3 Antibody
| 产品编号： | 4079753 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-VAMP-3 Antibody
Vesicle-associated membrane protein 3, VAMP-3, Cellubrevin, CEB, Synaptobrevin-3
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | VAMP-3 also known as cellubrevin is a vesicular transport protein and SNARE protein important in vesicle trafficking and exocytosis that helps regulate the release of critical components and processes such as blood clotting and inflammatory responses through the release of secretory granules and secretory vesicles. VAMP3 regulates the release of WPBs from endothelial cells. Weibel-Palade bodies (WPBs) are secretory organelles of endothelial cells that store the thrombogenic glycoprotein von Willebrand factor (vWF). Endothelial activation, for example by histamine and thrombin, triggers the Ca(2+)-dependent exocytosis of WPB that releases vWF into the vasculature and thereby initiates platelet capture and thrombus (blood clot) formation. VAMP3 is also critical to the release of proinflammatory compounds IL-6 and TNF-alpha.VAMP-3 is widely expressed in cells. |
| Immunogen【免疫原】 | Epitope: Near N-terminus KLH-conjugated linear peptide corresponding to human VAMP-3 near the N-terminus. |
| Application【应用】 | Research Sub Category Apoptosis - Additional Western Blotting Analysis: A 1:500 dilution from a representative lot detected VAMP-3 in 10 µg of Huvec and human brain tissue lysate. Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected VAMP-3 in PANC-1 cells. This Anti-VAMP-3 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of VAMP-3. Research Category Apoptosis & Cancer |
| Quality【质量】 | Evaluated by Western Blotting in PANC-1 cell lysate. Western Blotting Analysis: A 1:500 dilution of this antibody detected VAMP-3 in 10 µg of PANC-1 cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology), rat (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_004772 |
| UniProt accession no.【UniProt登记号】 | Q15836 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... VAMP3(9341) |
产品说明
| Target description【目标描述】 | ~13 kDa observed. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
