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CXCR2 antagonist, Cpd 19-CAS 473728-67-5-Calbiochem
| 产品编号： | 4080411 |
| 规格： | The CXCR2 antagonist, Cpd 19, also referenced under CAS 473728-67-5, controls the biological activity of CXCR2. |
| CAS NO： | 473728-67-5 |
| 包装规格： | 2 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
473728-67-5
CXCR2 antagonist, Cpd 19-CAS 473728-67-5-Calbiochem
3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H21N3O4 |
| Molecular weight | 343.38 |
| General description【一般描述】 | A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (>50% remaining after 30 min at 37°C). |
| Warning【警告】 | Toxicity: Regulatory Review (Z) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Merritt, J., et al. 2006. Bioorg. Med. Chem. Lett.16, 4107. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: 50 mg/mL, light brown |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 2 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
