AG 825-CAS 149092-50-2-Calbiochem

C₁₉H₁₅N₃O₃S₂

397.47

MFCD01074971

A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC₅₀ = 0.35 µM) relative to HER1 (IC₅₀ = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185^neu.
A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER-2 (neu/erbB-2, IC₅₀ = 0.35 µM) relative to HER-1 (IC₅₀ = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances the chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185^neu.

Cell permeable: yes
Target IC₅₀: 0.35 µM against HER2
Product does not compete with ATP.
Primary Target
HER2
Reversible: yes

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.

Ashton, J.M., et al. 2012. Cell Stem Cell11, 359.
Tsai, C.M., et al. 1996. Cancer Res.56, 1068.
Levitzki, A., and Gazit, A. 1995. Science267, 1782.
Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥94% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

yellow

DMSO: 10 mg/mL

ambient

−20℃

2 mg in Plastic ampoule

11 - Combustible Solids

WGK 3