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TGF-β RI Kinase Inhibitor III-CAS 356559-13-2-Calbiochem
| 产品编号： | 4080576 |
| 规格： | The TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| CAS NO： | 356559-13-2 |
| 包装规格： | 2 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
356559-13-2
TGF-β RI Kinase Inhibitor III-CAS 356559-13-2-Calbiochem
Transforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H21N3O2 · xHCl |
| Molecular weight | 335.40 (free base basis) |
| General description【一般描述】 | A cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product competes with ATP. Primary Target Activin receptor-like kinase 4, 5, 7 Reversible: yes Target IC50: 129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively |
| Warning【警告】 | Toxicity: Irritant (B) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol.289, F816. DaCosta Byfield, S., et al. 2004. Mol. Pharmacol.65, 744. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| color【颜色】 | light yellow |
| solubility【溶解性】 | DMSO: 20 mg/mL water: 3 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 2 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
