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单克隆抗肌球蛋白(骨骼,快速) 小鼠抗

Monoclonal Anti-Myosin (Skeletal, Fast)-Alkaline Phosphatase antibody produced in mouse
产品编号:4080900
规格:clone MY-32, purified from hybridoma cell culture
包装规格:0.2 ML
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40809000.2 ML4730
产品别名

单克隆抗肌球蛋白(骨骼,快速) 小鼠抗

Monoclonal Anti-Myosin (Skeletal, Fast)-Alkaline Phosphatase antibody produced in mouse

Monoclonal Anti-Myosin (Skeletal, Fast) antibody produced in mouse

基本信息
MDL number
MFCD00145920
NACRES
NA.41
General description【一般描述】
Monoclonal Anti-Myosin (Skeletal, Fast) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
定位于肌球蛋白重链上的表位。可对骨骼肌中发现的快速(II型)和新生儿肌动蛋白分子进行染色,但不会对培养细胞中的心肌、平滑肌或非肌肉肌球蛋白染色。能与人类横纹肌肉瘤发生反应。
Specificity【特异性】
Monoclonal Anti-Myosin (Skeletal, Fast) specifically binds to an epitope in adult rat skeletal myosin heavy chains IIa, IIb and IId (IIx) (in fast-twitch fibers)†. The antibody product is also reactive in humans, bovines, cats, rabbits, mice, guinea pigs and chickens.
Immunogen【免疫原】
兔肌肉肌球蛋白。
Application【应用】
Monoclonal Anti-Myosin (Skeletal, Fast) Alkaline Phosphatase antibody produced in mouse has been used for the detection and localization of skeletal muscle fast and neonatal myosins using immunohistochemistry. It may be used in muscle fiber typing, in studies of in vivo and in vitro muscle development and in the diagnosis of rhabdomyosarcomas.
使用单克隆小鼠抗肌球蛋白(骨骼/快速)作为一抗,以1:90000的稀释度,通过蛋白质印迹对来自具有过去损伤的运动员的血清样品中的肌球蛋白(快)水平进行测定。
Biochem/physiol Actions【生化/生理作用】
Myosin (Skeletal, Fast) is useful not only in fiber typing but also in detection of myogenic tumors. It enables retrospective as well as prospective fiber typing using formalin-fixed, paraffin-embedded material.
Myosins are motor proteins that interact with actin filaments to regulate cell movement. Myosins also modulate cell shape and signaling. Skeletal muscle myosins have three ′fast′ myosin heavy chains isoforms (IIa, IIx, and IIb), a ′slow′ beta-myosin heavy chain isoform and three major myosin light-chain (MLC) isoforms. These myosin isoforms regulate skeletal muscle shortening.
Physical form【外形】
Solution in 0.05 M Tris buffer, pH 8.0, containing 1% bovine serum albumin, 1 mM MgCl2, 50% glycerol, and 15 mM sodium azide.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
alkaline phosphatase conjugate
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
MY-32, monoclonal
form【形式】
buffered aqueous glycerol solution
species reactivity
chicken, rabbit, feline, mouse, rat, bovine, human, guinea pig
technique(s)
direct immunofluorescence: 1:150 using formalin-fixed, paraffin-embedded human or animal skeletal muscle sections
isotype【同位素/亚型】
IgG1
UniProt accession no.【UniProt登记号】
P12882
shipped in【运输】
wet ice
storage temp.【储存温度】
2-8℃
Gene Information
human ... MYH1(4619), MYH2(4620)
mouse ... Myh1(17879), Myh2(17882)
rat ... Myh1(287408), Myh2(691644)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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