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Anti-GABAA Receptor (α3 subunit) antibody produced in rabbit
| 产品编号： | 4081064 |
| 规格： | affinity isolated antibody, lyophilized powder |
| 包装规格： | 0.05 ML |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD03455039 |
| NACRES | NA.41 |
| General description【一般描述】 | GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes. |
| Immunogen【免疫原】 | peptide corresponding to amino acid residues 1-15 of human GABA(A) receptor α3 subunit. Identical in rat and mouse. Highly conserved (14/15 residues) in bovine. |
| Application【应用】 | Anti-GABAA Receptor (α3 subunit) antibody produced in rabbit is suitable for immunohistochemistry at a working dilution of 1:200 using rat brain frozen sections and immunoblotting at 1:200-1:300 using rat brain membranes. |
| Biochem/physiol Actions【生化/生理作用】 | The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. α3 is a subtype of GABAA receptor expressed selectively by serotonergic and GABAergic neurons. Serotonergic neurons express strong α3 immunoreactivity but, do not show any α1 immunoreactivity. On the contrary, GABAergic neurons express both α1 and α3 subunits. |
| Physical form【外形】 | Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | lyophilized powder |
| species reactivity | rat |
| technique(s) | immunohistochemistry: 1:200 using Rat brain frozen sections western blot: 1:200-1:300 using Rat brain membranes |
| UniProt accession no.【UniProt登记号】 | P20236 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... GABRA3(2556) mouse ... Gabra3(14396) rat ... Gabra3(24947) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
