Anti-TRPC1 antibody produced in rabbit

MFCD02686004

NA.41

Transient receptor potential cation channel subfamily C member 1 (TRPC1) is encoded by the gene mapped to human chromosome 3q22-24. The encoded protein is a member of the transient receptor potential (TRP) superfamily of cation channels and is distributed in both glomeruli and glomerular mesangial cells.

Synthetic protein corresponding to amino acids 557-571 of human TRPC1 (GenBank^® Accession No. P48995). The epitope is identical in mouse and rat and highly homologous in bovine and Xenopus.

Transient receptor potential cation channel subfamily C member 1 (TRPC1) facilitates Ca²⁺ entry upon store depletion in a variety of cell types by forming a multimeric complex with other TRPCs. The encoded protein is implicated in the odontoblast-like differentiation of human dental pulp cells (hDPCs). Mutation in the gene is associated with the development type 2 diabetes mellitus (T2D). Decreased expression of the gene leads to hepatocellular carcinoma cell proliferation and thus, TRPC1 can be considered as a potential therapeutic target for hepatocellular carcinoma.

Lyophilized at 0.3 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

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rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

lyophilized powder

rat

immunohistochemistry: suitable
western blot (chemiluminescent): suitable

Q9QX01

−20℃

human ... TRPC1(7220)
mouse ... Trpc1(22063)
rat ... Trpc1(89821)

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GHS06,GHS09

Danger

H301 + H311 - H411

P273 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P391 - P501

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 2

EUH032

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK 3

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges