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产品别名
Anti-Rac1 Antibody
Ras-related C3 Botulinum Toxin Substrate 1, p21-Rac1, Ras-like Protein TC25
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Rac is a member of the Rho family of small GTP-binding proteins, and plays roles in cytoskeletal actin organization as well as transformation. Rac is activated downstream of cdc42, or independently by Ras signaling, and in turn Rac stimulates Rho. Activation of Rac results in the formation of lamellipodia, whereas cdc42 stimulates filopodia formation, and Rho stimulates formation of actin stress fibers. Effectors of the Rac pathway include NADPH Oxidase and the SAPK1/JNK family of kinases. The latter pathway is activated by the PAK kinases, which are direct targets of Rac. |
| Specificity【特异性】 | Recognizes Rac1, does not cross react with Cdc42. Rac1 is a member of the Rho family of small GTPases. Small GTPases act as molecular switches in regulating a variety of biological response pathways by cycling from the GDP-bound (inactive) and GTP-bound (active) states. Rac regulates actin polymerization to form lamellipodia. |
| Immunogen【免疫原】 | Synthetic peptide corresponding to amino acids 130-141 of human Rac1 (KEKKLTPITYPQ-C). |
| Application【应用】 | Research Sub Category Cytoskeletal Signaling Anti-Rac1 Antibody is an antibody against Rac1 for use in WB. Research Category Signaling Optimal working dilutions must be determined by end user. |
| Quality【质量】 | Routinely evaluated by Western Blot on L6 lysates. Western Blot Analysis: 1:500 dilution of this lot detected RAC1 on 10 μg of L6 lysates. |
| Linkage【联系】 | Replaces: AB4202 |
| Physical form【外形】 | Purified rabbit polyclonal IgG in 0.02 M PBS with 0.15 M NaCl, pH 7.6 and 0.1% sodium azide as a preservative Format: Purified Protein A purified |
| Analysis Note【分析说明】 | Control Immunoblot/Immunoprecipitation: L6 Cell Lysate or Rat brain microsomal protein preparation Immunohistochemistry: Rat brain sections |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | rat, human, mouse |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NM_006908.4 |
| UniProt accession no.【UniProt登记号】 | P63000 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... RAC1(5879) |
产品说明
| Target description【目标描述】 | 21 kDa |
| Storage and Stability【储存及稳定性】 | Stable at 2-8°C in undiluted aliquots for up to 6 months from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
