Anti-phospho-GluR1 (Ser831) Antibody, clone N453, rabbit monoclonal

32160702

NA.41

L glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors that have been divided into 3 groups. Group I includes GRM1 and these receptors have been shown to activate phospholipase C. GRM1 expression has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries.

Predicted cross-reactivity with human, mouse and chicken
Recognizes GluR1 phosphorylated on Serine 831.

KLH-conjugated, synthetic peptide containing the sequence ...QQ[pS]IN… in which pS corresponds to phospho-serine at position 831 of the GluR1 mature chain. Sequence is identical in human, rat, mouse and chicken.

Western Blot Analysis:
A 1:1,000-1:4,000 dilution of this lot detected phosphorylated GluR1 from a rat brain microsomal preparation (Catalog # 12-144).

Research Category
Neuroscience
Anti-phospho-GluR1 (Ser831) Antibody, clone N453 detects level of phospho-GluR1 (Ser831) & has been published & validated for use in WB.
Research Sub Category
Neurotransmitters & Receptors

routinely evaluated by western blot

Replaces: 05-823

Cultured supernantant in 0.05% sodium azide.

Control
Rat brain

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

rabbit

100

culture supernatant

primary antibodies

N453, monoclonal

chicken, human, mouse, rat

Upstate^®

western blot: suitable

IgG

NP_000818

P42261

dry ice

human ... GRIA1(2890)

106 kDa

Stable for 1 year at -20°C from date of receipt.
For maximum recovery of product, centrifuge the vial prior to removing the cap.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 1