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Anti-IFNAR-1 Antibody, clone MARI-5A3
产品别名
Anti-IFNAR-1 Antibody, clone MARI-5A3
interferon (alpha, beta and omega) receptor 1, beta-type antiviral protein, alpha-type antiviral protein, Type I interferon receptor 1, Cytokine receptor family 2 member 1, interferon-beta receptor 1, Cytokine receptor class-II member 1, IFN-alpha-REC, i
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Interferon alpha/beta receptor 1 (IFNAR-1) is a single-pass type I membrane protein containing three fibronectin type-III domains and is a member of the type II cytokine receptor family. IFNAR-1 serves as an interferon receptor specific to interferons alpha and beta, a family of type I interferons critical to the promotion and the linking of adaptive and innate immune response. Type I interferons all bind to a heterodimeric receptor composed of two subunits, IFNAR-1 and IFNAR-2. The binding of the type I IFNs initializes tyrosine phosphorylation for several proteins such as; IFNR alpha/beta subunits, JAKs, STAT, and TYK2 proteins. |
| Specificity【特异性】 | This antibody recognizes the extracellular domain of IFNAR-1. |
| Immunogen【免疫原】 | Recombinant protein corresponding to the extracellular domain of mouse IFNAR-1. |
| Application【应用】 | Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.) Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.) Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.) Neutralizing Assay: A previous lot was used by an independent laboratory in neutralization studies. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.) Anti-IFNAR-1 Antibody, clone MARI-5A3 is an antibody against IFNAR-1 for use in FC, IP, WB, NEUT. |
| Quality【质量】 | Evaluated by Flow Cytometry in BALB/c splenocytes. Flow Cytometry Analysis: 5 µg of this antibody detected IFNAR-1 in BALB/c splenocytes. |
| Physical form【外形】 | Protein G Purified Format: Purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | MARI-5A3, monoclonal |
| species reactivity | mouse |
| technique(s) | flow cytometry: suitable immunoprecipitation (IP): suitable neutralization: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_034638 |
| UniProt accession no.【UniProt登记号】 | P33896 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 63 kDa calculated |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
