广州伟伯科技有限公司
您的位置:首页 > 产品中心 > Anti-MAP2 Antibody, clone 3C19, ZooMAb® Rabbit Monoclonal
产品搜索:

Anti-MAP2 Antibody, clone 3C19, ZooMAb® Rabbit Monoclonal

产品编号:4082823
规格:recombinant, expressed in HEK 293 cells
包装规格:25 μL,4 X 25 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
408282325 μL2350
40828234 X 25 μL4400
产品别名

Anti-MAP2 Antibody, clone 3C19, ZooMAb® Rabbit Monoclonal

Microtubule-associated protein 2

产品性质
biological source【生物来源】
rabbit (recombinant)
recombinant【重组】
expressed in HEK 293 cells
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
3C19, monoclonal
recombinant monoclonal
product line【产品线】
ZooMAb® learn more
form【形式】
lyophilized
mol wt【分子量】
calculated mol wt 199.53 kDa
observed mol wt ~260 kDa
species reactivity
rat, human, mouse
packaging【包装】
antibody small pack of 25 μL
greener alternative product characteristics【环保替代产品特性】
Waste Prevention
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
enhanced validation【增强验证】
recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)
immunocytochemistry: suitable using 1:100
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable using 1:100
western blot: suitable using 1:1,000
isotype【同位素/亚型】
IgG
UniProt accession no.【UniProt登记号】
P11137
greener alternative category【环保替代产品分类】
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
Gene Information
human ... MAP2(4133)
基本信息
General description【一般描述】
ZooMAb antibodies represent an entirely new generation of recombinant monoclonal antibodies.

Each ZooMAb antibody is manufactured using our proprietary recombinant expression system, purified to homogeneity, and precisely dispensed to produce robust and highly reproducible lot-to-lot consistency. Only top-performing clones are released for use by researchers. Each antibody is validated for high specificity and affinity across multiple applications, including its most commonly used application. ZooMAb antibodies are reliably available and ready to ship when you need them.

Learn more about ZooMAb here.
Specificity【特异性】
Clone 3C19 is a ZooMAb rabbit recombinant monoclonal antibody that specifically detects human Microtubule-associated protein 2. It targets an epitope with in 17 amino acids from the C-terminal half.
Immunogen【免疫原】
KLH-conjugated linear peptide corresponding to 17 amino acids from the C-terminal half of human Microtubule-associated protein 2 (MAP2).
Application【应用】
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected MAP2 in mouse brain tissue lysate.

Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected MAP2 in E18 cortical cells.

Immunohistochemistry (Paraffin) Analysis: A 1:100 dilution from a representative lot detected MAP2 in rat brain, mouse brain, human brain and in rat kidney tissue sections.
Anti-MAP2, clone 3C19 ZooMAb, Cat. No. ZRB2290, is a recombinant Rabbit Monoclonal Antibody that specifically targets Microtubule-associated protein 2 (MAP2) and has been tested for use in Immunocytochemistry, Immunohistochemistry (Paraffin), and Western Blotting.
Physical form【外形】
Purified recombinant rabbit monoclonal antibody IgG, lyophilized in PBS with 5% Trehalose, normal appearance a coarse or translucent resin. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 μL.
Reconstitution【重悬】
30 μg/mL after reconstitution at 25 μL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
Legal Information【法律信息】
ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany
产品说明
Target description【目标描述】
Microtubule-associated protein 2 (UniProt: P11137; also known as MAP-2) is encoded by the MAP2 gene (Gene ID: 4133) in human. MAPs are a family of thermostable cytoskeletal proteins that bind to and stabilize microtubules. MAP4 is expressed ubiquitously while MAP1 and MAP2 are expressed primarily in neurons. MAP2 is an abundant neuronal cytoskeletal protein that binds to tubulin and stabilizes microtubules against depolymerization. In the central nervous system, MAP2 is confined to neuronal cell bodies and dendrites. However, some axons may also have small amounts of MAP2. It is shown to be essential for the development and maintenance of neuronal morphology. Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene) have been identified in neurons. The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation. All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif. MAP2 can be phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2) that causes its detachment from microtubules and results in their disassembly. This ZooMAb recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and stability over conventional monoclonals.
Storage and Stability【储存及稳定性】
Recommend storage of lyophilized product at 2-8℃; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 μL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8℃, or -20℃ for long term storage. Avoid repeated freeze-thaws.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
广州伟伯科技有限公司 版权所有 CopyRight ©2006-2024, All Rights Reserved
工信部备案号:粤ICP备08114744号   Page Run Time: 0.0091