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SB 242084 Hydrochloride-CAS 181632-25-7-Calbiochem
产品别名
181632-25-7
SB 242084 Hydrochloride-CAS 181632-25-7-Calbiochem
5-HT 2C receptor antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H19ClN4O2 · xHCl |
| Molecular weight | 394.85 (free base basis) |
| General description【一般描述】 | A selective, brain-penetrant 5-HT2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2B receptor (pKi 6.8-7.0) and 5-HT2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC50 values reported at 2.08 µM. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target 5-HT2C |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Manvich, D. F., et al. 2012. J Pharmacol. Exp. Ther.342, 761. Burghardt, N. S., et al. 2007. Biol Psychiatry62, 1111. Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther.23, 1. Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Kennett G.A., et al. 1997. Neuropharmacol. 36, 609. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | off-white to pale yellow pale yellow |
| solubility【溶解性】 | water: soluble |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
