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InSolution IKK Inhibitor VII-CAS 873225-46-8-Calbiochem
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083413 | 500 μG | 1180 |
产品别名
873225-46-8
InSolution IKK Inhibitor VII-CAS 873225-46-8-Calbiochem
IKK 16, (4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII
(4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII, IKK 16
基本信息
| Empirical Formula【经验(实验)分子式】 | C28H29N5OS |
| Molecular weight | 483.63 |
| General description【一般描述】 | A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Reversible: yes Primary Target IKK-2, IKK complex, and IKK-1 |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 10 mM (500 µg/103 µL) sterile-filtered solution of IKK Inhibitor VII (Cat. No. 401486) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Waelchli, R., et al. 2006. Bioorg. Med. Chem. Lett.16, 108. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| storage temp.【储存温度】 | −70℃ |
| packaging【包装】 | Packaged under inert gas |
