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InSolution Phorbol-12-myristate-13-acetate-CAS 16561-29-8-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083414 | 2 MG | 1480 |
产品别名
16561-29-8
InSolution Phorbol-12-myristate-13-acetate-CAS 16561-29-8-Calbiochem
12-O-Tetradecanoyl-phorbol-13-acetate, PMA, TPA
基本信息
| Empirical Formula【经验(实验)分子式】 | C36H56O8 |
| Molecular weight | 616.83 |
| MDL number | MFCD00036736 |
| General description【一般描述】 | Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin (>Cat. No. 344270, >Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Secondary Target Ca2+-ATPase Reversible: yes Primary Target PKC |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 10 mM (2 mg/324 µL) solution of Phorbol-12-myristate-13-acetate (Cat. No. 524400) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Use only fresh DMSO for preparing further dilutions. |
| Other Notes【其他说明】 | Powell, D.J., et al. 2003. Mol. Cell Biol.23, 7794. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA92, 8443. Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem.55, 168. Macfarlane, D.E., and O′Donnell, P.S. 1993. Leukemia7, 1846. Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol.31, 1101. Hortelano, S., et al. 1992. J. Biol. Chem.267, 24937. Kontny, E., et al. 1992. Eur. J. Pharmacol.227, 333. Zanaboni, P.B., et al. 1992. J. Appl. Physiol.73, 2011. Saltis, J., et al. 1991. J. Biol. Chem.266, 261. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA82, 2774. Perchellet, J. 1985. Carcinogenesis6, 567. Nishizuka, Y. 1984. Science255, 1365. Mastro, A. 1982. Lymphokines6, 263. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| storage temp.【储存温度】 | −70℃ |
| InChI | 1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1 |
| InChI key | PHEDXBVPIONUQT-RGYGYFBISA-N |
| packaging【包装】 | Packaged under inert gas |
安全信息
| Pictograms【象形图】 | GHS06,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H311 + H331 - H315 - H317 - H319 - H334 - H351 |
| Precautionary Statements | P201 - P280 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 2 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |
