Oxidized ATP (oATP)-CAS 71997-40-5-Calbiochem

C₁₀H₁₄N₅O₁₃P₃

505.17

MFCD00056956

A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X₇ purinergic receptors in J774 mouse macrophages. Does not affect P2_γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X₇ receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca²⁺ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.

Reversible: no

Toxicity: Standard Handling (A)

Vergani, A., et al. 2013. Diabetes62, 1665.
DellʹAntonio, G., et al. 2002. Arthritis Rheum.46, 3378.
Wiley, J.S., et al. 1994. Br. J. Pharmacol.112, 946.

Murgia, M., et al. 1992. J. Biol. Chem.268, 8199.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

powder

Calbiochem^®

OK to freeze
protect from light

white

water: 50 mg/mL

−20℃

11 - Combustible Solids

WGK 3